1st steps to Reversing Diabetes utilising gene modified stem cells


In this innovative medicinal technique Professor John S. Yu genetically modified stem cells to produce Vascular endothelial growth factor (VEGF) – a protein that stimulates neo-vascularization. The cells were then used to treat diabetes in mice:http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042177

The study found “Human BMSCs expressing VEGF and PDX1 reversed hyperglycemia in more than half of the diabetic mice and induced overall improved survival and weight maintenance in all mice”

Most interestingly the study found that endogenous  β-cell regeneration seemed to drive the benefits.



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